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O-PTIR: Beyond the limits of traditional IR microscopy

O-PTIR: Beyond the limits of traditional IR microscopy

O-PTIR: Beyond the
limits of traditional
IR microscopy

Submicron
spatial resolution

Submicron
spatial resolution

Submicron
spatial resolution

Non-contact measurement

Non-contact measurement

Non-contact measurement

All the benefits of ATR
without its contact
related limitations

All the benefits of ATR
without its contact
related limitations

All the benefits of ATR
without its contact
related limitations

IR+Raman/IR plus Raman

Same spot.

Same resolution.

Same time.

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Submicron simultaneous IR+Raman microscopy combines optical photothermal infrared spectroscopy (O-PTIR) with Raman

FTIR and Raman infrared spectroscopy are well established, mature technologies that have their practical and theoretical limitations. Now, with the breakthrough technique of O-PTIR, those limitations are shattered. The novel use of a dual purpose visible light probe not only provides for submicron IR spatial resolution, but it also doubles as the Raman excitation laser, thus providing submicron simultaneous IR+Raman spectroscopy on a single platform – the mIRage+R microscope. This generates complementary and confirmatory analysis through IR and Raman spectroscopy for a more detailed and thorough characterization for the ultimate in vibrational spectroscopic synergy.

Circle animated illustration showing function of visible light probe

O-PTIR microscopy overcomes several of the key limitations of traditional FTIR microscopy such as poor spatial resolution and complex sample preparation. By working in reflection mode, it generates high quality spectra without any dispersive scatter artifacts that are comparable to FTIR transmission/ATR spectra.

While at the same time, O-PTIR is not affected at all by fluorescence interference, a key limitation of Raman spectroscopy, thus allowing for submicron molecular characterization that is completely fluorescence free.

O-PTIR: Optical photothermal
infrared spectroscopy

Achieve submicron IR spatial resolution
in non-contact reflection mode

Discover O-PTIR

IR+Raman/IR plus RamanSame spot.
Same resolution.
Same time.

Discover IR+Raman
Product shot of the mIRage O-PTIR and IR+Raman scope

mIRage IR Microscope

Changing the field of IR spectroscopy
Optical Photothermal Infrared spectroscopy overcomes the key limitations of FTIR and Raman by providing for a sub-micron, non-contact and fluorescence free rapid analysis. When combined with simultaneous Raman, it provides for a unique complementary and confirmatory sample analysis experience.

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Wide applications capabilities

O-PTIR enables unique breakthrough applications in the fields of failure analysis, pharmaceuticals, life science and more

See applications
Illustration showing IR+Raman analysis of computer hard drive contamination
Illustration showing O-PTIR analysis of a fingerprint for sub micron particles of TNT

Publications

Super-resolution infrared imaging of polymorphic amyloid aggregates directly in neurons

Simultaneous optical photothermal infrared (O-PTIR) and Raman spectroscopy of submicrometer atmospheric particles

Two-dimensional correlation analysis of highly spatially resolved simultaneous IR and Raman spectral imaging of bioplastics composite using optical photothermal infrared and Raman spectroscopy

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Photothermal Spectroscopy Corp

325 Chapala Street
Santa Barbara, CA 93101

Phone: (805) 845-6568
Email: info [at] photothermal.com