mIRage®
The mIRage platform is modular microscope that delivers high performance submicron IR spectroscopy and imaging with a range of options to address broad application flexibility.
Non-contact reflection IR measurement with FTIR-quality spectra and no artifacts
Fast, easy to use with little to no sample preparation and spectroscopy in seconds
Overcomes the limitations of Raman spectroscopy
About mIRage
mIRage overcomes the IR diffraction limit using Optical Photothermal Infrared (O-PTIR) Spectroscopy, in which a tunable pulsed mid-IR laser induces a photothermal response from the sample surface. This thermal response is measured using a colinear visible probe laser focused on the sample. Spatial resolution is determined by the diffraction limited spot size of the visible laser (around 500 nm), therefore independent of the IR wavenumber, unlike traditional diffraction limited techniques.
Transmission FTIR quality spectra in non-contact reflection mode
As mIRage is an optical microscope based platform, measurements are collected quickly and easily, without the need for sample contact, unlike ATR spectroscopy.
Additionally, O-PTIR provides spectra comparable to FTIR, ideal for database searches, without the dispersive artifacts observed in ATR. By operating in refl ection mode, the need for thin samples is also eliminated.
Simultaneous IR and Raman spectral searching, complementary and confirmatory
Traditionally IR and Raman spectral searching has been done separately and the data has been analyzed separately. Now, with Wiley’s recent release of the KnowItAll™ multi-technique of simultaneous searching, the hit list information is displayed in a graphical 2D scatter plot. This multi-dimensional approach plots the HQI of the unknown IR spectrum against the HQI of the unknown Raman spectrum dramatically speeding up data analysis. This greatly simplified display of spectral matches in graphical rather than tabular form greatly improves the accuracy of the identification. IR search results can confirm Raman search results and vice-versa, all simultaneously.
IR+Raman: Same time. Same spot. Same resolution.
The world’s first simultaneous IR+Raman microscopy system is a unique dual modality platform with all the advantages of an O-PTIR and Raman microscope combined. O-PTIR, optical photothermal microscopy, using a visible probe laser, is combined with Raman for applications in polymers, defect analysis, microplastic detection and red blood cells.
Spectra, line scans and 2D maps can now be collected from the same spot at the same time, opening up new research opportunities and a more thorough characterization of your sample.
FeaturefindIR
Detect, Select, Measure, Identify
featurefindIR can accurately and automatically measure and chemically identify particles and micro-plastics from sub-micron to mm’s in size, overcoming the limitations of conventional FTIR and Raman techniques.
Learn about how the featurefindIR can support your research into microplastics, pharma and failure analysis and other defect applications
Submicron O-PTIR + Raman of microplastics
mIRage locates PS (0.9 µm, 2.0 µm, 4.5 µm and 10 µm) and PMMA beads (3.0 µm) in salt crystal mixture in hi-res IR images at key absorption bands. Distortion free spectra, even amongst salt crystals at hotspots, confirm the identity of the microplastics and readily searched against IR database. Importantly, and unlike traditional FTIR/QCL systems, spectra are consistent, regardless of particle shape or size when measured in reflection mode – no dispersive scatter artefacts.
Single bacterial cell simultaneous submicron IR+Raman microscopy
A: Visible image of bacterial cells. Orange box indicate region of IR imaging. B: O-PTIR infrared image at 1655cm-1, with 50nm step size. Collection time ~1 min. C: Simultaneous, submicron IR and Raman spectra collected from the indicated spot on the single bacterial cell. Spectra are normalized to the most intense band spectra are ~20sec accumulations. O-PTIR spectra are collected with a Dual Range (C-H/FP) QCL, covering 3000-2700, 1800-950cm-1 in a single unit. O-PTIR spectra are raw (no processing). Raman spectra are baseline corrected.
SNR of the OPTIR (~500nm spot) is ~4000:1 (RMS, taking amide band intensity as the peak and the baseline noise at the amide I position measured on a CaF2 blank) with ~20 sec accumulations.
IR+Raman analysis of red blood cells
The mIRage-R provides unparalleled productive measurements red blood cells
Left: Optical image with selected 70 x 70 µm area for subsequent Raman imaging
Right: IR+Raman spectra collected off of a selected red blood cell (~500 nm resolution).
Technical article:
Traditional IR vs Raman Spectroscopy —and how to carry out both simultaneously
Wide range of applications
mIRage provides unique data for numerous applications and material types, including:
- Microplastics
- Failure analysis
- Microelectronics
- Polymers and composites
- Defect identification
- Geological sciences
- Forensics
Microplastics
The mIRage uniquely provides accurate measurement of a wide range of critical <20 µm microplastics that are poorly resolved by other IR and Raman techniques.
Biopharma
Integrating sub-micron chemical and morphological analysis into routine particle control strategies is now a reality with the mIRage platform, submicron multimodal IR microscope.
MiRage provides routine analysis of submicron chemical and morphological analysis of small particulate matter, overcoming the limitations of other spectroscopy techniques.
Semiconductor
mIRage provides the ability to identify unknowns of small size using sub-micron O-PTIR or simultaneous IR+Raman.
Application note:
Sub-micron IR and Raman spectroscopy for chemical identification of microplastics
mIRage accessories
mIRage Spectroscopy options
Counter-propagating mode and other mIRage spectroscopy capabilities to extend research flexibility.
Multi-modal Imaging options
Complimentary O-PTIR techniques such as simultaneous Raman and co-located Fluorescence.
mIRage Environmental options
mIRage environmental options broaden the applications range with heating, cooling and flow cells.
More products
Sub-500nm Laser Scanning O-PTIR Microscope for High-Speed Imaging. With co-located Fluorescence and Raman spectroscopy.
The mIRage-LS addresses both life science applications and the broad application set of multiuser facilities where the most advanced vibrational spectroscopy needs are required.
Optimized for Value. Same high performance as the mIRage platform but leveraged for dedicated O-PTIR only measurements and a focused range of accessories for application flexibility.
Need more information?
Discover how O-PTIR technology can elevate your research or help solve your toughest challenges. Our team are happy to assist and answer your questions.