Microplastics released from disposable medical devices and their toxic responses in Caenorhabditis elegans

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Zhong et. al found that the smaller the particles, the more ecotoxic they become. This novel O-PTIR technique provides the precise chemical identification of these small fragments towards identification of their original sources. Microplastic fragments smaller than 5µm can be identified in high confidence due to this method.

Microplastic fragments increases germ cell apoptosis (programmed cell death) and disrupts intestinal barriers in toxin-sensitive C. elegans, thus shortening their life span.

This study determined that experimentally heated and deformed medical devices can be directly analyzed by the submicron O-PTIR mIRage microscope, while retaining high spectral quality. Thus, virgin samples could be probed directly for capturing the most accurate representation of the heat treatment to both the plastic surface and the released microplastics fragments.

Data from the article suggests microplastics from disposable polypropylene medical devices are more toxic than microplastics released from PVC-based devices. Therefore, understanding the chemical nature of the microplastic fragments will provide a profound design direction on device safety and end-of-life disposal strategy.

 

Professor Tong Zhou,
University of Science and Technology of China
Hefei, Anhui, China

 

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What is O-PTIR?

The O-PTIR technique overcomes the IR diffraction limit associated with traditional IR microscopy techniques by illuminating the sample with a mid-IR pulsed tunable quantum cascade laser (QCL) and measuring infrared absorption, indirectly with a visible laser beam.

When the QCL laser is tuned to a wavelength that excites molecular vibrations in the sample, absorption occurs, thereby creating photothermal effects, e.g., sample surface expansion and a change in refractive index.

Application note:

Life science applications of sub-500nm IR microscopy and spectroscopy with co-located fluorescence imaging

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